Kisspeptin-10 — what the (45-54) in the name means
Kisspeptin is a family, not a molecule. The number after the name tells you which fragment is in the vial, and the fragments differ by thousands of daltons.
Kisspeptin-10 is a ten-residue fragment corresponding to residues 45 to 54 of the parent kisspeptin peptide, CAS 374675-21-5, molecular weight 1302.45 g/mol. Kisspeptin is a family rather than a single molecule, and the number in the name is what tells you which fragment a vial actually contains.
By the Bench Grade Research Team ·
Kisspeptin identity data
| Property | Value |
|---|---|
| CAS Registry Number | 374675-21-5 |
| Molecular formula | C63H83N17O14 |
| Molecular weight | 1302.45 g/mol |
| Fragment | Residues 45-54 of the parent |
| Length | 10 residues |
The family, and why the number matters
The KISS1 gene product is processed into peptides of different lengths, conventionally named by residue count — kisspeptin-54, kisspeptin-14, kisspeptin-13, kisspeptin-10. They share a common C-terminal region but differ enormously in mass: kisspeptin-54 is roughly five times the weight of kisspeptin-10.
A vial labelled simply Kisspeptin has not told you which one it contains. Since a protocol written for one fragment and executed with another is wrong by a factor of several in molar terms, the number is not a detail.
Residue numbering explained
The (45-54) notation counts from the start of the parent sequence, so kisspeptin-10 is the last ten residues of the 54-residue form. The naming convention differs between papers — some number from the precursor and some from the mature peptide — which is why the CAS number is a more reliable identifier than the name.
What the published work examined
Three studies in our research library, from 2017 to 2023, are clinical investigations concerning neuroendocrine signalling. They are linked below and describe research findings only.
References
Primary literature for the compounds discussed above. Links open the record on PubMed.
- Effects of Kisspeptin on Sexual Brain Processing and Penile Tumescence in Men With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial Mills EG, et al. JAMA Netw Open. 2023. PMID 36735255 → · summary
- Effects of Kisspeptin Administration in Women With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial Thurston L, et al. JAMA Netw Open. 2022. PMID 36287566 → · summary
- Kisspeptin modulates sexual and emotional brain processing in humans Comninos AN, et al. J Clin Invest. 2017. PMID 28112678 → · summary
Primary sources
- Effects of Kisspeptin on Sexual Brain Processing and Penile Tumescence in Men With Hypoactive Sexual Desire Disorder: A Randomized Clinical TrialJAMA Netw Open · 2023
- Effects of Kisspeptin Administration in Women With Hypoactive Sexual Desire Disorder: A Randomized Clinical TrialJAMA Netw Open · 2022
- Kisspeptin modulates sexual and emotional brain processing in humansJ Clin Invest · 2017
Frequently asked questions
- What does kisspeptin-10 mean?
- A ten-residue fragment corresponding to residues 45 to 54 of the parent kisspeptin peptide. The number in the name identifies which fragment of the KISS1 gene product is present — kisspeptin-54, -14, -13 and -10 differ by thousands of daltons.
- What is the molecular weight of kisspeptin-10?
- 1302.45 g/mol, formula C63H83N17O14, CAS 374675-21-5. For comparison, kisspeptin-54 is roughly five times that mass, which is why the fragment number matters.
- How do I know which kisspeptin fragment I have?
- Check the molecular weight on the Certificate of Analysis against the fragment named on the label. A figure near 1302 g/mol is kisspeptin-10. The CAS number is a more reliable identifier than the name, since numbering conventions differ between papers.
Compounds discussed in this guide
More on identification
- Semax — an ACTH fragment with a Pro-Gly-Pro tailSemax is ACTH (4-7) with a proline-glycine-proline tail attached. That tail is a design decision shared with Selank, and it explains both compounds.
- Selank — a tuftsin analog, and the tail it shares with SemaxSelank is tuftsin with the same Pro-Gly-Pro tail Semax carries. Two compounds, one structural idea, and no methionine to worry about.
- Dihexa — why it is not really a peptideDihexa is an angiotensin IV analog built with non-amino-acid components. Peptide COA conventions apply to it only partly, and that trips people up.
Who publishes this guide
- Who sells it
- Bench Grade Peptides LLC, a US supplier of lyophilized synthetic peptides for laboratory research use only. It works with US manufacturing partners rather than running a facility of its own. Is Bench Grade Peptides legit? →
- Certificates of Analysis
- 139 third-party Certificates of Analysis covering 39 of 44 live products, published per lot in a public library anyone can read before ordering. A very recent lot can appear a few days after it enters the catalogue. COA library →
- Ships from
- Florida, by UPS, to US addresses only (no international shipping). The registered address in Dover, Delaware is the legal address only. Shipping →
- Use
- For laboratory research use only — not for human or veterinary use. Not a drug, supplement or medical device. Compliance and research use →
All products discussed in this guide are supplied by Bench Grade Peptides for laboratory research use only. Not for human or veterinary use.