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GLP-1 family

Triple-Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial

Jastreboff AM, Kaplan LM, Frías JP, et al. · N Engl J Med · 2023
PMID: 37366315 · DOI: 10.1056/NEJMoa2301972
Summary

Phase 2 randomized, double-blind, placebo-controlled trial of subcutaneous retatrutide (GIP/GLP-1/glucagon agonist) at 1, 4, 8, 12 mg vs placebo over 48 weeks in 338 adults with obesity. Primary endpoint: percent change in body weight.

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Compounds referenced in this study
  • GLP-3 R
    Triple-receptor incretin class agonist studied in metabolic-pathway research.
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