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GLP-1 family

Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes

Marso SP, Daniels GH, Brown-Frandsen K, et al. · N Engl J Med · 2016
PMID: 27295427 · DOI: 10.1056/NEJMoa1603827
Summary

Multinational double-blind randomized trial (LEADER) in 9340 adults with type 2 diabetes and high cardiovascular risk; once-daily subcutaneous liraglutide 1.8 mg vs placebo, median 3.8 years. Primary endpoint: composite cardiovascular death, nonfatal MI, nonfatal stroke.

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Compounds referenced in this study
  • GLP-1 S
    Single-receptor incretin class agonist studied in incretin-pathway metabolic research.
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