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GLP-1 family

Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes

Marso SP, Bain SC, Consoli A, et al. · N Engl J Med · 2016
PMID: 27633186 · DOI: 10.1056/NEJMoa1607141
Summary

Phase 3 double-blind randomized trial (SUSTAIN-6) in 3297 adults with type 2 diabetes and high cardiovascular risk; once-weekly subcutaneous semaglutide 0.5 or 1.0 mg vs placebo, 104 weeks. Primary endpoint: composite cardiovascular death, nonfatal MI, nonfatal stroke.

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Compounds referenced in this study
  • GLP-1 S
    Single-receptor incretin class agonist studied in incretin-pathway metabolic research.
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