CJC-1295 with DAC — the other molecule, and how to tell them apart
The DAC form is 279 daltons heavier than the no-DAC form and has its own CAS. One number on the COA separates them.
CJC-1295 with DAC is a distinct molecule from the no-DAC form, not a variant of it. It carries an added drug-affinity complex group, giving a molecular weight of 3647.13 g/mol against 3367.89 for the no-DAC form — a difference of 279 daltons that a Certificate of Analysis will show plainly.
By the Bench Grade Research Team ·
CJC-1295 with DAC identity data
| Property | With DAC | No DAC |
|---|---|---|
| Molecular weight | 3647.13 g/mol | 3367.89 g/mol |
| Molecular formula | C165H269N47O46 | C152H252N44O42 |
| Also known as | CJC-1295 DAC | Mod GRF (1-29) |
| Modification | Maleimidoproprionic acid group | None |
What DAC actually is
Drug affinity complex refers to a maleimidoproprionic acid group covalently attached to the peptide. It is a chemical modification of the molecule rather than a formulation choice or an additive, which is why the two forms have different formulas, different masses and separate identities.
The 279-dalton test
This is the fastest check available. Read the mass spectrometry figure on the COA: approximately 3647 for the DAC form, approximately 3368 for the no-DAC form. The gap is far larger than any measurement uncertainty, so there is no ambiguity — provided the COA reports a mass at all, which is the more common failure.
Why both forms exist
The modification was designed to extend circulating half-life by binding to serum albumin. Whether that is desirable depends entirely on what a given experiment is measuring, which is why both forms remain in the research market rather than one superseding the other.
What the published work examined
Two studies in our research library, both from 2006, concern growth hormone secretion measured in clinical research settings. They are linked below.
References
Primary literature for the compounds discussed above. Links open the record on PubMed.
- Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog Ionescu M, et al. J Clin Endocrinol Metab. 2006. PMID 17018654 → · summary
- Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults Teichman SL, et al. J Clin Endocrinol Metab. 2006. PMID 16352683 → · summary
- Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats Svensson J, et al. Growth Horm IGF Res. 1999. PMID 10373343 → · summary
- Ipamorelin, the first selective growth hormone secretagogue Raun K, et al. Eur J Endocrinol. 1998. PMID 9849822 → · summary
Primary sources
- Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analogJ Clin Endocrinol Metab · 2006
- Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adultsJ Clin Endocrinol Metab · 2006
- Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in ratsGrowth Horm IGF Res · 1999 · animal study
- Ipamorelin, the first selective growth hormone secretagogueEur J Endocrinol · 1998 · animal study
Frequently asked questions
- What is the difference between CJC-1295 with and without DAC?
- They are chemically distinct molecules. The DAC form carries an added maleimidoproprionic acid group, giving it a molecular weight of 3647.13 g/mol against 3367.89 for the no-DAC form — a 279 dalton difference with its own formula.
- How do I tell which form of CJC-1295 I have?
- Read the mass on the Certificate of Analysis. About 3647 g/mol is the DAC form; about 3368 is the no-DAC form. The gap far exceeds measurement uncertainty, so the only ambiguity comes from a COA that reports no mass at all.
- Why does the DAC modification exist?
- It was designed to extend circulating half-life through albumin binding. Whether that is useful depends on what an experiment is measuring, which is why both forms remain in the research market.
Compounds discussed in this guide
More on identification
- Selank — a tuftsin analog, and the tail it shares with SemaxSelank is tuftsin with the same Pro-Gly-Pro tail Semax carries. Two compounds, one structural idea, and no methionine to worry about.
- Dihexa — why it is not really a peptideDihexa is an angiotensin IV analog built with non-amino-acid components. Peptide COA conventions apply to it only partly, and that trips people up.
- What is the Wolverine blend? BPC-157 and TB-500the wolverine blendWolverine blend is a market nickname for a BPC-157 and TB-500 pairing. What is in the vial, what the research covers, what the record says about safety, and what the dosing question actually turns on.
Who publishes this guide
- Who sells it
- Bench Grade Peptides LLC, a US supplier of lyophilized synthetic peptides for laboratory research use only. It works with US manufacturing partners rather than running a facility of its own. Is Bench Grade Peptides legit? →
- Certificates of Analysis
- 139 third-party Certificates of Analysis covering 39 of 44 live products, published per lot in a public library anyone can read before ordering. A very recent lot can appear a few days after it enters the catalogue. COA library →
- Ships from
- Florida, by UPS, to US addresses only (no international shipping). The registered address in Dover, Delaware is the legal address only. Shipping →
- Use
- For laboratory research use only — not for human or veterinary use. Not a drug, supplement or medical device. Compliance and research use →
All products discussed in this guide are supplied by Bench Grade Peptides for laboratory research use only. Not for human or veterinary use.