Tissue repairPreclinical
PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation
Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, et al. · Gastroenterology · 2008
PMID: 18061177 · DOI: 10.1053/j.gastro.2007.10.026
Summary
Mechanistic study in intestinal epithelial cells and DSS- and TNBS-induced murine colitis models characterizing PepT1-mediated KPV uptake and NF-kappaB modulation. Endpoints: MPO activity, histology, cytokine mRNA.
Citation hosted by NCBI. We link to the source so the researcher can read the abstract, full text, or references-cited list directly.
Compounds referenced in this study
- View product →KPVC-terminal α-MSH tripeptide studied in inflammation and gut-mucosal research.
Guides covering this compound
- Working out concentration and volume — the arithmeticConcentration, volume and mass are one equation rearranged three ways. The method, the unit traps, the peptide-content correction, and worked examples you can substitute your own figures into.5 min read
- Thymosin Alpha-1 — identity and the clinical literatureA 28-residue N-acetylated thymic peptide with more clinical literature behind it than almost any compound in this market. Identity data and what the studies covered.2 min read
- LL-37 (Cathelicidin) — identity and handling of a cationic peptide37 residues carrying an unusually high positive charge. That charge governs its solubility, its adsorption to surfaces, and why it needs different labware.2 min read
- Selank — a tuftsin analog, and the tail it shares with SemaxSelank is tuftsin with the same Pro-Gly-Pro tail Semax carries. Two compounds, one structural idea, and no methionine to worry about.2 min read
More Tissue repair citations
- Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative ColitisMol Ther · 2017
- The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin ResistanceCell Metab · 2015
- The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivityPhysiol Rep · 2019