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Tissue repairPreclinical

The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance

Lee C, Zeng J, Drew BG, et al. · Cell Metab · 2015
PMID: 25738459 · DOI: 10.1016/j.cmet.2015.02.009
Summary

Discovery study identifying the 16-aa mitochondrial-derived peptide MOTS-c. Characterized in skeletal muscle and in mice on high-fat diet. Endpoints: AMPK activation, insulin sensitivity, body composition.

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Compounds referenced in this study
  • MOTS-c
    Mitochondrial-derived 16-residue peptide studied in metabolic-homeostasis and exercise-physiology research.
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