MOTS-c
Mitochondrial-derived 16-residue peptide studied in metabolic-homeostasis and exercise-physiology research.
MOTS-c is a sixteen-amino-acid peptide encoded not in the nuclear genome but within the mitochondrial 12S rRNA gene — one of a small class of mitochondrial-derived peptides that upended the assumption that mitochondria only export energy. It acts as a signaling molecule, translocating to the nucleus under metabolic stress and influencing gene expression.
The research literature connects MOTS-c to AMPK activation, glucose handling in skeletal muscle, and exercise-responsive metabolic programs; population genetics work has also examined a MOTS-c variant enriched in long-lived cohorts. It sits at the intersection of metabolism, exercise physiology, and aging biology — three of the most active fields in peptide research.
As a mid-length peptide with a defined sequence, MOTS-c verifies cleanly by HPLC and mass spectrometry, and each Bench Grade lot ships with its Certificate of Analysis.
Published research
- The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity
- The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance
- The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance
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