SS-31

Mitochondria-targeting tetrapeptide studied in mitochondrial dysfunction and cardiolipin research.

SS-31 is supplied by Bench Grade Peptides as a lyophilized powder in a sealed, lot-numbered vial, for laboratory research use only — not for human or veterinary use.

Its published Certificate of Analysis (lot 00011/0011, analyzed September 3, 2026) is from AV Analytics, a third-party laboratory, and reports 99.79% purity by HPLC; every published lot is listed on the product's COA page. Vials ship at ambient temperature in protective packaging from Florida (Bench Grade Peptides LLC is registered in Dover, Delaware), with storage notes on the lot's certificate.

SS-31 is a synthetic aromatic-cationic tetrapeptide, D-Arg-2′,6′-dimethyl-Tyr-Lys-Phe-NH2 (CAS 736992-21-5, C32H49N9O5, 639.79 g/mol). It belongs to the Szeto-Schiller family of peptides, a series designed around alternating aromatic and basic residues, and the D-arginine at the first position is there for protease resistance in research preparations.

The published research on SS-31 concentrates on the inner mitochondrial membrane. Investigators have reported that the peptide associates with cardiolipin, the phospholipid that organizes the electron-transport complexes, and the literature examines that interaction in isolated mitochondria, cultured cell models and rodent models, with readouts such as membrane potential, electron-transport activity and reactive-oxygen-species production.

Because the sequence is short and carries a non-standard residue, identity work on SS-31 relies on mass confirmation against the expected 639.79 g/mol. Certificates for published lots are listed on the compound's COA page. SS-31 is supplied as laboratory research material only.

Research use only. Everything on this page describes laboratory research. This compound is supplied strictly for in-vitro research use; it has not been evaluated or approved by the FDA and is not for human or veterinary use, and nothing here is a protocol or a recommendation.

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